Citation: Mesci C, Erbil HH, Karakurt Y, Akçakaya AA. Clin Exp Ophthalmol. 2012 May-Jun;40(4):e197-207. doi: 10.1111/j.1442-9071.2011.02611.x. Epub 2011 Aug 3. PMID: 21668789

ABSTRACT

Background:

To evaluate the long term results following deep sclerectomy with mitomycin-C-SKgel implant (DSMMC-SKgel), mitomycin-C (DSMMC) and trabeculectomy.

Design:

Comparative case series, Göztepe Training and Educational Hospital.

Participants:

Ninetyone open angle glaucoma patients

Methods:

DSMMC–SKgel, DSMMC and trabeculectomy operations were performed in 28, 30 and 33 eyes respectively.

Main outcome measures:

Intraocular pressures (IOP), distance corrected visual acuities (DCVA) were measured preoperatively and postoperatively at days 1,7 and months 1,3,6,12,18,24,30,36,48.

Results:

At month 48, deep sclerectomy groups had better DCVAs, and in all groups mean IOPs, number of medications were significantly lower and DCVAs were worse than preoperative values. Mean IOPs in trabeculectomy group at week 1, month 1 and 3 were significantly lower than those in DSMMC group. Mean IOPs in DSMMC-SKGel group at week 1 and month 1 were significantly lower than those in DSMMC group. Mean preoperative IOPs, postoperative IOPs following 3rd month, complete (IOP ? 21 mmHg and ?18mmHg without medication) and qualified (IOP ? 21 mmHg and ?18mmHg with or without medication) success rates of all groups were not statistically different. Rate of complications such as hyphema, hypotony, shallow anterior chamber, bleb leak, bleb fibrosis, cataract, choroidal detachment and macular edema were found to be significantly higher in Trabeculectomy group (p < 0.05). No significant difference in the mean post-laser goniopuncture IOPs was found between the two deep sclerectomy groups during the follow-up.

Conclusions:

DSMMC, DSMMC-SKgel and trabeculectomy operations were almost equally effective in lowering IOP at long term follow-up, but complication rates were higher after trabeculectomy operations.

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