Citation: Grieshaber MC, Pienaar A, Olivier J, Stegmann R. Canaloplasty for primary open-angle glaucoma: long-term outcome. Br J Ophthalmol. 2010 Nov;94(11):1478-82. doi: 10.1136/bjo.2009.163170. PubMed PMID: 20962352.

ABSTRACT

Background/Aims:

To study the safety and effectiveness of 360° viscodilation and tensioning of Schlemm canal (canaloplasty) in black African patients with primary open-angle glaucoma (POAG).

Methods:

Sixty randomly selected eyes of 60 consecutive patients with POAG were included in this prospective study. Canaloplasty comprised 360° catheterisation of Schlemm’s canal by means of a flexible microcatheter with distension of the canal by a tensioning 10-0 polypropylene suture.

Results:

The mean preoperative intraocular pressure pressure (IOP) was 45.0 ± 12.1 mm Hg. The mean follow-up time was 30.6 ± 8.4 months. The mean IOP at 12 months was 15.4± 5.2 mm Hg (n=54), at 24 months 16.3 ± 4.2 mm Hg (n = 51) and at 36 months 13.3 ± 1.7 mm Hg (n=49). For IOP ? 21 mm Hg, complete success rate was 77.5% and qualified success rate was 81.6% at 36 months. Cox regression analysis showed that preoperative IOP (HR = 1.003, 95% CI = 0.927 to 1.085; p = 0.94), age (HR = 1.000, CI = 0.938 to 1.067; p = 0.98) and sex (HR = 3.005, CI=0.329 to 27.448; p=0.33) were all not significant predictors of IOP reduction to ? 21 mm Hg. Complication rate was low (Descemet’s detachment n=2, elevated IOP n = 1, false passage of the catheter n = 2).

Conclusion:

Canaloplasty produced a sustained long-term reduction of IOP in black Africans with POAG independent of preoperative IOP. As a bleb-independent procedure, canaloplasty may be a true alternative to classic filtering surgery, in particular in patients with enhanced wound healing and scar formation.

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