Canaloplasty: Circumferential Viscodilation And Tensioning Of Schlemm’s Canal Using A Flexible Microcatheter For The Treatment Of Open-Angle Glaucoma In Adults: Interim Clinical Study Analysis.


Cited: Canaloplasty versus Trabeculectomy

Lewis RA, von Wolff K, Tetz M, Korber N, Kearney JR, Shingleton B, Samuelson TW.

Augen-Tagesklinik Gross Pankow, Gross Pankow, Germany.




To evaluate the safety and efficacy of circumferential viscodilation and tensioning of the inner wall of Schlemm’s canal in a new surgical procedure for the treatment of open-angle glaucoma (OAG).


Fourteen clinical sites in the United States and Germany.


In this international multicenter prospective study of adult patients with OAG having glaucoma surgery, patients with qualifying preoperative intraocular pressure (IOP) of at least 16 mm Hg or higher and open angles were eligible. Evaluation was performed at baseline and 1 day, 1 week, and 1, 3, 6, and 12 months preoperatively. After a nonpenetrating dissection technique to expose Schlemm’s canal was performed, a flexible microcatheter (iTrack 250A, iScience Interventional) was used to dilate the full circumference of the canal by injecting sodium hyaluronate 1.4% (Healon GV) during catheterization. A suture loop was placed in the canal to apply tension to the trabecular meshwork. High-resolution ultrasound imaging was used to assess Schlemm’s canal and anterior segment angle morphology, including distension of the trabecular meshwork caused by the tensioning suture. Data analysis was performed in 2 groups: Group 1, in which patients met all inclusion criteria, and Group 2, made up of Group 1 patients who had successful suture placement.


Group 1 comprised 94 patients and Group 2, 74 patients. The mean baseline IOP in Group 1 was 24.7 mm Hg+/-4.8 (SD) on a mean of 1.9+/-1.0 medications per patient. In Group 2 (patients with sutures), the mean IOP was 16.1+/-4.7 mm Hg 3 months postoperatively, 15.6+/-4.0 mm Hg at 6 months, and 15.3+/-3.8 mm Hg at 1 year. Medication use dropped to a mean of 0.6+/-0.9 per patient at 12 months. Suture tensioning was an apparent contributing factor in achieving surgical success. Patients with measurable trabecular meshwork distension from suture tension had a mean IOP of 15.9+/-5.2 mm Hg at 6 months and 14.5+/-3.0 mm Hg at 12 months. Surgical and postsurgical adverse events were reported in 15 of 94 patients (16%) and included hyphema (3), elevated IOP greater than 30 mm Hg (3), Descemet’s tear (1), hypotony (1), choroidal effusion (1), and exposed closure suture with eyelid edema and erythema epiphora (1); 4 patients were subsequently converted to trabeculectomy.


Circumferential viscodilation and tensioning of Schlemm’s canal was a safe and effective surgical procedure to reduce IOP in adult patients with OAG.




Sick of High IOPs? Tired of taking Drops?

Find Out If You Qualify for Canaloplasty Share

Opt In Image
Subscribe Now!
Fill out below form and get updates! It’s FREE!

Author: Dr David Richardson

David Richardson, MD. is a Board-certified Ophthalmologist (Eye Surgeon) in California and an Adjunct Assistant Professor Of Clinical Ophthalmology at Keck School of Medicine of University of California. Dr. Richardson completed his undergraduate studies at University of Southern California, where he graduated Magna Cum Laude and received many academic awards. He earned his medical degree at the prestigous Harvard Medical School with scholarships from Phi Beta Kappa and Phi Kappa Phi. He was also awarded with Harvard Medical Linnane Scholarship and Harvard National Scholarship. He also serves as Vice Chief of Staff at San Gabriel Valley Medical Center. He has authored a patient-centered book on Cataract, "So, You've Got A Cataract?" Dr. Richardson is among an elite group of glaucoma surgeons in the country performing the highly specialized canaloplasty procedure. In fact, patients have traveled half way around the world to have canaloplasty by Dr. Richardson. Dr. Richardson has performed thousands of advanced cataract and Canaloplasty glaucoma procedures with excellent results! Dr. David Richardson accepts new patients at his office in San Marino, California.

Share This Post On
WP-Backgrounds by InoPlugs Web Design and Juwelier Schönmann